Assay Detail
Binding
CHEMBL759468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2C (CHEMBL401) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, phencyclidine-like pharmacology, and antiischemic potential of meta-substituted 1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.98 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69034 | — | — | 1 | 8.22 |
| CHEMBL71302 | — | — | 1 | 7.43 |
| CHEMBL307988 | — | — | 1 | 7.09 |
| CHEMBL414875 | — | — | 1 | 7.04 |
| CHEMBL304964 | — | — | 1 | 6.94 |
| CHEMBL304550 | — | — | 1 | 6.64 |
| CHEMBL67637 | — | — | 1 | 6.55 |
| CHEMBL68100 | — | — | 1 | 6.49 |
| CHEMBL68156 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69034 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL71302 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL307988 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL414875 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL304964 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL304550 | — | Ki | = | 231.0 | nM | 6.64 |
| CHEMBL67637 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL68100 | — | Ki | = | 324.0 | nM | 6.49 |
| CHEMBL68156 | — | Ki | = | 422.0 | nM | 6.38 |