Assay Detail
Binding
CHEMBL759470
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Inhibition of protein kinase C alpha
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and protein kinase C inhibitory activities of indane analogs of balanol
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.11 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177635 | — | — | 1 | 7.66 |
| CHEMBL427118 | — | — | 1 | 7.40 |
| CHEMBL367162 | — | — | 1 | 7.16 |
| CHEMBL177308 | — | — | 1 | 6.80 |
| CHEMBL367127 | — | — | 1 | 6.54 |
| CHEMBL367457 | — | — | 1 | - |
| CHEMBL444877 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177635 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL427118 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL367162 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL177308 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL367127 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL367457 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL444877 | — | IC50 | > | 50000.0 | nM | - |