Assay Detail
Binding
CHEMBL759579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Protease-activated receptor (PAR-1) using [3H]-s-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2, 10 nM (Kd= 15 nM)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 8.97 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267059 | — | — | 1 | 10.40 |
| CHEMBL275946 | — | — | 1 | 9.15 |
| CHEMBL428311 | — | — | 1 | 9.09 |
| CHEMBL7610 | RWJ-54003 | — | 1 | 8.89 |
| CHEMBL269345 | — | — | 1 | 8.66 |
| CHEMBL268328 | — | — | 1 | 8.62 |
| CHEMBL7627 | — | — | 1 | 7.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267059 | — | Kd | = | 0.04 | nM | 10.40 |
| CHEMBL275946 | — | Kd | = | 0.7 | nM | 9.15 |
| CHEMBL428311 | — | Kd | = | 0.82 | nM | 9.09 |
| CHEMBL7610 | RWJ-54003 | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL269345 | — | Kd | = | 2.2 | nM | 8.66 |
| CHEMBL268328 | — | Kd | = | 2.4 | nM | 8.62 |
| CHEMBL7627 | — | Kd | = | 10.7 | nM | 7.97 |