Assay Detail
Binding
CHEMBL759583
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Inhibitory constant against bovine phenylethanolamine N-methyl-transferase
31
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Phenylethanolamine N-methyltransferase (CHEMBL2331) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 5.73 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287837 | — | — | 1 | 6.66 |
| CHEMBL38681 | — | — | 1 | 6.66 |
| CHEMBL41647 | — | — | 1 | 6.47 |
| CHEMBL275595 | — | — | 1 | 6.43 |
| CHEMBL337144 | — | — | 1 | 6.42 |
| CHEMBL342625 | — | — | 1 | 6.32 |
| CHEMBL26717 | — | — | 1 | 6.25 |
| CHEMBL39493 | — | — | 1 | 6.25 |
| CHEMBL43183 | — | — | 1 | 6.23 |
| CHEMBL43021 | — | — | 1 | 6.19 |
| CHEMBL39928 | — | — | 1 | 6.19 |
| CHEMBL290890 | — | — | 1 | 6.13 |
| CHEMBL336026 | — | — | 1 | 6.01 |
| CHEMBL40081 | — | — | 1 | 5.77 |
| CHEMBL287360 | — | — | 1 | 5.77 |
| CHEMBL290010 | — | — | 1 | 5.64 |
| CHEMBL135908 | — | — | 1 | 5.46 |
| CHEMBL39125 | — | — | 1 | 5.34 |
| CHEMBL36909 | — | — | 1 | 5.19 |
| CHEMBL41689 | — | — | 1 | 5.12 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | — | 1 | 5.01 |
| CHEMBL35982 | — | — | 3 | 4.89 |
| CHEMBL288524 | — | — | 1 | 4.57 |
| CHEMBL288525 | — | — | 1 | 4.29 |
| CHEMBL41079 | — | — | 1 | - |
| CHEMBL19969 | — | — | 1 | - |
| CHEMBL278059 | — | — | 1 | - |
| CHEMBL39492 | — | — | 1 | - |
| CHEMBL282700 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287837 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL38681 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL41647 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL275595 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL337144 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL342625 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL26717 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL39493 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL43183 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL43021 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL39928 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL290890 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL336026 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL287360 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL40081 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL290010 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL135908 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL39125 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL36909 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL41689 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL35982 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL35982 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL35982 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL288524 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL288525 | — | Ki | = | 51000.0 | nM | 4.29 |
| CHEMBL41079 | — | Ki | = | 120000.0 | nM | - |
| CHEMBL19969 | — | Ki | = | 1600000.0 | nM | - |
| CHEMBL278059 | — | Ki | = | 280000.0 | nM | - |
| CHEMBL39492 | — | Ki | = | 470000.0 | nM | - |
| CHEMBL282700 | — | Ki | = | 140000.0 | nM | - |