Assay Detail
Binding
CHEMBL759774
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Inhibition of Phenylethylamine N-Methyltransferase (PNMT) using radiochemical assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Phenylethanolamine N-methyltransferase (CHEMBL2331) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Binding orientation of amphetamine and norfenfluramine analogues in the benzonorbornene and benzobicyclo[3.2.1]octane ring systems at the active site of phenylethanolamine N-methyltransferase (PNMT)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 4.63 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70357 | — | — | 1 | 4.92 |
| CHEMBL30294 | — | — | 1 | 4.82 |
| CHEMBL303481 | — | — | 1 | 4.50 |
| CHEMBL71964 | — | — | 1 | 4.29 |
| CHEMBL308587 | — | — | 1 | - |
| CHEMBL60005 | — | — | 1 | - |
| CHEMBL49263 | — | — | 1 | - |
| CHEMBL70384 | — | — | 1 | - |
| CHEMBL302285 | — | — | 1 | - |
| CHEMBL304541 | — | — | 1 | - |
| CHEMBL71566 | — | — | 1 | - |
| CHEMBL314304 | — | — | 1 | - |
| CHEMBL71771 | — | — | 1 | - |
| CHEMBL305281 | — | — | 1 | - |
| CHEMBL299436 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70357 | — | Ki | = | 12100.0 | nM | 4.92 |
| CHEMBL30294 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL303481 | — | Ki | = | 31800.0 | nM | 4.50 |
| CHEMBL71964 | — | Ki | = | 51100.0 | nM | 4.29 |
| CHEMBL308587 | — | Ki | = | 1803000.0 | nM | - |
| CHEMBL60005 | — | Ki | = | 1296000.0 | nM | - |
| CHEMBL49263 | — | Ki | = | 479000.0 | nM | - |
| CHEMBL70384 | — | Ki | = | 1429000.0 | nM | - |
| CHEMBL302285 | — | Ki | = | 350000.0 | nM | - |
| CHEMBL304541 | — | Ki | = | 8900000.0 | nM | - |
| CHEMBL71566 | — | Ki | = | 801000.0 | nM | - |
| CHEMBL314304 | — | Ki | = | 191000.0 | nM | - |
| CHEMBL71771 | — | Ki | = | 106000.0 | nM | - |
| CHEMBL305281 | — | Ki | = | 204000.0 | nM | - |
| CHEMBL299436 | — | Ki | = | 258000.0 | nM | - |