Assay Detail
Functional
CHEMBL759839
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Inhibitory activity against Entamoeba histolytica pyrophosphate-dependent phosphofructokinase (PFK)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Entamoeba histolytica |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.33 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298852 | — | — | 1 | 4.70 |
| CHEMBL416301 | — | — | 1 | 4.40 |
| CHEMBL54004 | — | — | 1 | 4.16 |
| CHEMBL55371 | — | — | 1 | 4.05 |
| CHEMBL52251 | (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | - |
| CHEMBL55988 | — | — | 1 | - |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | - |
| CHEMBL54747 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298852 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL416301 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL54004 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL55371 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL52251 | (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | > | 3000000.0 | nM | - |
| CHEMBL55988 | — | IC50 | > | 3000000.0 | nM | - |
| CHEMBL923 | RISEDRONIC ACID | IC50 | > | 3000000.0 | nM | - |
| CHEMBL54747 | — | IC50 | = | 1000000.0 | nM | - |