Assay Detail
Binding
CHEMBL759849
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cyclic GMP sensitive phosphodiesterase PDE 2 of human lung
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL2652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.60 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | — | 1 | 4.92 |
| CHEMBL19224 | PAPAVERINE | 3.0 | 1 | 4.77 |
| CHEMBL150764 | BUFROLIN | 2.0 | 1 | 4.10 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | - |
| CHEMBL18701 | RO-201724 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL19224 | PAPAVERINE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL150764 | BUFROLIN | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL28079 | ZAPRINAST | IC50 | = | 170000.0 | nM | - |
| CHEMBL18701 | RO-201724 | IC50 | = | 390000.0 | nM | - |