Assay Detail
Binding
CHEMBL759913
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In vitro inhibition of phosphodiesterase (PDE I).
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Imidazotriazinone inhibitors of the Ca2+-calmodulin sensitive phosphodiesterase (PDE I)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.85 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367927 | — | — | 1 | 7.07 |
| CHEMBL426937 | — | — | 1 | 6.35 |
| CHEMBL176346 | — | — | 1 | 6.19 |
| CHEMBL173317 | — | — | 1 | 6.11 |
| CHEMBL174270 | — | — | 1 | 6.04 |
| CHEMBL173510 | — | — | 1 | 5.99 |
| CHEMBL354843 | — | — | 1 | 5.94 |
| CHEMBL426946 | — | — | 1 | 5.91 |
| CHEMBL366938 | — | — | 1 | 5.80 |
| CHEMBL355748 | — | — | 1 | 5.75 |
| CHEMBL366491 | — | — | 1 | 5.74 |
| CHEMBL366999 | — | — | 1 | 5.60 |
| CHEMBL369172 | — | — | 1 | 5.51 |
| CHEMBL368198 | — | — | 1 | 5.46 |
| CHEMBL368322 | — | — | 1 | 5.40 |
| CHEMBL369830 | — | — | 1 | 5.34 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 5.22 |
| CHEMBL369431 | — | — | 1 | - |
| CHEMBL173275 | — | — | 1 | - |
| CHEMBL170449 | — | — | 1 | - |
| CHEMBL367221 | — | — | 1 | - |
| CHEMBL170228 | — | — | 1 | - |
| CHEMBL440593 | CI-930 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367927 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL426937 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL176346 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL173317 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL174270 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL173510 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL354843 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL426946 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL366938 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL355748 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL366491 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL366999 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL369172 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL368198 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL368322 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL369830 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL28079 | ZAPRINAST | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL369431 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL173275 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL170449 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL367221 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL170228 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL440593 | CI-930 | IC50 | > | 100000.0 | nM | - |