Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL759984

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and micellar substrate with deoxycholate (DOC)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Group 10 secretory phospholipase A2 (CHEMBL4342)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2.
Beaton HG, Bennion C, Connolly S, Cook AR, Gensmantel NP, Hallam C, Hardy K, Hitchin B, Jackson CG, Robinson DH.
J Med Chem (1994) 37 : 557 -559
PubMed 8126692 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.47 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL152921 1 6.92
CHEMBL152402 1 6.42
CHEMBL152031 1 6.10
CHEMBL357750 1 5.66
CHEMBL347066 1 5.35
CHEMBL347055 1 5.14
CHEMBL150732 1 5.07
CHEMBL152773 1 4.82
CHEMBL152115 1 4.72
CHEMBL322409 1 4.52
CHEMBL152562 1 -
CHEMBL149343 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL152921 IC50 = 120.0 nM 6.92
CHEMBL152402 IC50 = 380.0 nM 6.42
CHEMBL152031 IC50 = 790.0 nM 6.10
CHEMBL357750 IC50 = 2200.0 nM 5.66
CHEMBL347066 IC50 = 4500.0 nM 5.35
CHEMBL347055 IC50 = 7300.0 nM 5.14
CHEMBL150732 IC50 = 8500.0 nM 5.07
CHEMBL152773 IC50 = 15000.0 nM 4.82
CHEMBL152115 IC50 = 19000.0 nM 4.72
CHEMBL322409 IC50 = 30000.0 nM 4.52
CHEMBL152562 IC50 > 100000.0 nM -
CHEMBL149343 IC50 > 30000.0 nM -