Assay Detail
Binding
CHEMBL760057
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Inhibition of purine nucleoside phosphorylase against the enzyme from calf spleen in 1 mM phosphate
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Spleen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.58 | 10.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159640 | — | — | 1 | 10.17 |
| CHEMBL162255 | — | — | 1 | 9.80 |
| CHEMBL159758 | — | — | 1 | 9.20 |
| CHEMBL345655 | — | — | 1 | 7.96 |
| CHEMBL160043 | — | — | 1 | 7.77 |
| CHEMBL310364 | — | — | 1 | 7.70 |
| CHEMBL351815 | — | — | 1 | 7.68 |
| CHEMBL349615 | — | — | 1 | 7.64 |
| CHEMBL159908 | — | — | 1 | 7.62 |
| CHEMBL79410 | — | — | 1 | 7.60 |
| CHEMBL311300 | PELDESINE | 2.0 | 1 | 7.60 |
| CHEMBL79784 | — | — | 1 | 7.60 |
| CHEMBL354926 | — | — | 1 | 7.44 |
| CHEMBL310202 | — | — | 1 | 7.29 |
| CHEMBL159960 | — | — | 1 | 7.24 |
| CHEMBL82087 | — | — | 1 | 7.16 |
| CHEMBL162751 | — | — | 1 | 7.09 |
| CHEMBL351205 | — | — | 1 | 7.08 |
| CHEMBL81966 | — | — | 1 | 6.92 |
| CHEMBL159471 | — | — | 1 | 6.83 |
| CHEMBL285627 | — | — | 1 | 6.80 |
| CHEMBL158599 | — | — | 1 | 6.62 |
| CHEMBL81731 | — | — | 1 | 6.58 |
| CHEMBL309679 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159640 | — | IC50 | = | 0.067 | nM | 10.17 |
| CHEMBL162255 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL159758 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL345655 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL160043 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL310364 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL351815 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL349615 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL159908 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL79410 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL311300 | PELDESINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL79784 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL354926 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL310202 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL159960 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL82087 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL162751 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL351205 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL81966 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL159471 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL285627 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL158599 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL81731 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL309679 | — | IC50 | = | 270.0 | nM | 6.57 |