Assay Detail
Functional
CHEMBL760106
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Aryl-1,2,3,4-tetrahydrochromeno[3,4-f]quinolin-3-ones as a novel class of nonsteroidal progesterone receptor agonists: effect of A-ring modification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 7.94 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 9.82 |
| CHEMBL416411 | — | — | 1 | 8.55 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.54 |
| CHEMBL286446 | — | — | 1 | 8.49 |
| CHEMBL35429 | — | — | 1 | 8.35 |
| CHEMBL34015 | — | — | 1 | 8.28 |
| CHEMBL36564 | — | — | 1 | 8.20 |
| CHEMBL32812 | — | — | 1 | 8.12 |
| CHEMBL34824 | — | — | 1 | 8.06 |
| CHEMBL35525 | — | — | 1 | 8.06 |
| CHEMBL285705 | — | — | 1 | 8.05 |
| CHEMBL34589 | — | — | 1 | 8.01 |
| CHEMBL284475 | — | — | 1 | 8.00 |
| CHEMBL286595 | — | — | 1 | 7.85 |
| CHEMBL36065 | — | — | 1 | 7.85 |
| CHEMBL286158 | — | — | 1 | 7.80 |
| CHEMBL32603 | — | — | 1 | 7.77 |
| CHEMBL286822 | — | — | 1 | 7.41 |
| CHEMBL34882 | — | — | 1 | 7.33 |
| CHEMBL36076 | — | — | 1 | 7.32 |
| CHEMBL286130 | — | — | 1 | 6.91 |
| CHEMBL33909 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL416411 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL286446 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL35429 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL34015 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL36564 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL32812 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL34824 | — | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL35525 | — | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL285705 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL34589 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL284475 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL286595 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL36065 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL286158 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL32603 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL286822 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL34882 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL36076 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL286130 | — | EC50 | = | 124.0 | nM | 6.91 |
| CHEMBL33909 | — | EC50 | = | 1300.0 | nM | 5.89 |