Assay Detail
Functional
CHEMBL760108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | T47D |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Aryl-1,2,3,4-tetrahydrochromeno[3,4-f]quinolin-3-ones as a novel class of nonsteroidal progesterone receptor agonists: effect of A-ring modification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.81 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 9.48 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.74 |
| CHEMBL286446 | — | — | 1 | 8.00 |
| CHEMBL35429 | — | — | 1 | 7.96 |
| CHEMBL36564 | — | — | 1 | 7.83 |
| CHEMBL32603 | — | — | 1 | 7.74 |
| CHEMBL34015 | — | — | 1 | 7.65 |
| CHEMBL284475 | — | — | 1 | 7.63 |
| CHEMBL34824 | — | — | 1 | 7.60 |
| CHEMBL35525 | — | — | 1 | 7.58 |
| CHEMBL416411 | — | — | 1 | 7.57 |
| CHEMBL285705 | — | — | 1 | 7.46 |
| CHEMBL36065 | — | — | 1 | 7.43 |
| CHEMBL32812 | — | — | 1 | 7.29 |
| CHEMBL286158 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | EC50 | = | 0.33 | nM | 9.48 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL286446 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL35429 | — | EC50 | = | 10.9 | nM | 7.96 |
| CHEMBL36564 | — | EC50 | = | 14.8 | nM | 7.83 |
| CHEMBL32603 | — | EC50 | = | 18.3 | nM | 7.74 |
| CHEMBL34015 | — | EC50 | = | 22.6 | nM | 7.65 |
| CHEMBL284475 | — | EC50 | = | 23.5 | nM | 7.63 |
| CHEMBL34824 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL35525 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL416411 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL285705 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL36065 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL32812 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL286158 | — | EC50 | = | 63.0 | nM | 7.20 |