Assay Detail
Binding
CHEMBL760163
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In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brain
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.14 | 10.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292092 | — | — | 1 | 10.11 |
| CHEMBL63064 | — | — | 1 | 9.80 |
| CHEMBL63065 | — | — | 1 | 9.77 |
| CHEMBL481537 | PK-11195 | — | 1 | 9.08 |
| CHEMBL72521 | — | — | 1 | 8.32 |
| CHEMBL443526 | — | — | 1 | 7.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292092 | — | Ki | = | 0.078 | nM | 10.11 |
| CHEMBL63064 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL63065 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL481537 | PK-11195 | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL72521 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL443526 | — | Ki | = | 18.1 | nM | 7.74 |