Assay Detail
Binding
CHEMBL760186
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.95 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435037 | — | — | 1 | 7.00 |
| CHEMBL422003 | — | — | 1 | 6.96 |
| CHEMBL345420 | — | — | 1 | 6.92 |
| CHEMBL154481 | — | — | 1 | 6.26 |
| CHEMBL347597 | — | — | 1 | 6.22 |
| CHEMBL345909 | — | — | 1 | 6.21 |
| CHEMBL514432 | GINKOLIDE B | — | 1 | 6.06 |
| CHEMBL156402 | — | — | 1 | 6.00 |
| CHEMBL433516 | — | — | 1 | 5.79 |
| CHEMBL158006 | — | — | 1 | 5.78 |
| CHEMBL348623 | — | — | 1 | 5.62 |
| CHEMBL3349895 | — | — | 1 | 5.37 |
| CHEMBL347433 | — | — | 1 | 5.11 |
| CHEMBL346787 | — | — | 1 | 5.06 |
| CHEMBL1868593 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435037 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL422003 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL345420 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL154481 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL347597 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL345909 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL514432 | GINKOLIDE B | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL156402 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL433516 | — | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL158006 | — | Ki | = | 1670.0 | nM | 5.78 |
| CHEMBL348623 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL3349895 | — | Ki | = | 4260.0 | nM | 5.37 |
| CHEMBL347433 | — | Ki | = | 7840.0 | nM | 5.11 |
| CHEMBL346787 | — | Ki | = | 8640.0 | nM | 5.06 |
| CHEMBL1868593 | — | Ki | = | 12600.0 | nM | 4.90 |