Assay Detail
Binding
CHEMBL760187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Structure-activity relationships of phomactin derivatives as platelet activating factor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.55 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297624 | — | — | 1 | 7.62 |
| CHEMBL148491 | — | — | 1 | 7.58 |
| CHEMBL150892 | — | — | 1 | 7.51 |
| CHEMBL346391 | — | — | 1 | 7.30 |
| CHEMBL151688 | — | — | 1 | 7.10 |
| CHEMBL348494 | PHOMACTIN | — | 1 | 6.92 |
| CHEMBL148549 | — | — | 1 | 6.89 |
| CHEMBL151310 | — | — | 1 | 6.75 |
| CHEMBL151075 | — | — | 1 | 6.75 |
| CHEMBL147337 | — | — | 1 | 6.47 |
| CHEMBL149102 | — | — | 1 | 6.39 |
| CHEMBL421954 | — | — | 1 | 6.26 |
| CHEMBL147079 | — | — | 1 | 6.00 |
| CHEMBL345748 | — | — | 1 | 5.89 |
| CHEMBL150968 | — | — | 1 | 4.77 |
| CHEMBL358635 | — | — | 1 | 4.52 |
| CHEMBL356428 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297624 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL148491 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL150892 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL346391 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL151688 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL348494 | PHOMACTIN | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL148549 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL151310 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL151075 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL147337 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL149102 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL421954 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL147079 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL345748 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL150968 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL358635 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL356428 | — | IC50 | > | 280000.0 | nM | - |