Assay Detail
Binding
CHEMBL760188
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration required to inhibit PAF binding to rabbit platelet membrane
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Synthesis and biological activity of MK 287 (L-680,573): a potent, specific and orally active paf receptor antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.41 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296958 | KADSURENONE | — | 1 | 6.82 |
| CHEMBL112481 | VERAGUENSIN | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296958 | KADSURENONE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL112481 | VERAGUENSIN | IC50 | = | 1000.0 | nM | 6.00 |