Assay Detail
Binding
CHEMBL760193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit platelets
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.72 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29067 | — | — | 1 | 8.30 |
| CHEMBL28902 | — | — | 1 | 7.62 |
| CHEMBL28595 | — | — | 1 | 7.54 |
| CHEMBL31714 | — | — | 1 | 7.43 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29067 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL28902 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL28595 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL31714 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL603 | ZAFIRLUKAST | Ki | > | 50000.0 | nM | - |