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Assay Detail

CHEMBL760195

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Platelet-activating factor receptor (CHEMBL5136)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

Synthesis and structure-activity relationships of a series of novel benzopyran-containing platelet activating factor antagonists.
Guinn DE, Summers JB, Heyman HR, Conway RG, Rhein DA, Albert DH, Magoc T, Carter GW.
J Med Chem (1992) 35 : 2055 -2061
PubMed 1317924 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 28 5.61 7.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL280164 APAFANT 2.0 1 7.01
CHEMBL65132 1 6.85
CHEMBL264497 1 6.80
CHEMBL62873 1 6.78
CHEMBL63111 1 6.48
CHEMBL66414 1 6.46
CHEMBL62812 1 6.41
CHEMBL64094 1 6.18
CHEMBL66537 1 6.16
CHEMBL61680 1 6.03
CHEMBL65144 1 6.03
CHEMBL65228 1 5.80
CHEMBL303312 1 5.49
CHEMBL61014 1 5.48
CHEMBL304427 1 5.43
CHEMBL65556 1 5.38
CHEMBL62650 1 5.36
CHEMBL65199 1 5.26
CHEMBL61678 1 5.26
CHEMBL65089 1 5.05
CHEMBL62822 1 4.93
CHEMBL302863 1 4.80
CHEMBL62322 1 4.77
CHEMBL62503 1 4.69
CHEMBL65377 1 4.68
CHEMBL65715 1 4.63
CHEMBL291432 1 4.60
CHEMBL61627 1 4.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL280164 APAFANT Ki = 98.0 nM 7.01
CHEMBL65132 Ki = 142.0 nM 6.85
CHEMBL264497 Ki = 157.0 nM 6.80
CHEMBL62873 Ki = 167.0 nM 6.78
CHEMBL63111 Ki = 331.0 nM 6.48
CHEMBL66414 Ki = 345.0 nM 6.46
CHEMBL62812 Ki = 390.0 nM 6.41
CHEMBL64094 Ki = 656.0 nM 6.18
CHEMBL66537 Ki = 690.0 nM 6.16
CHEMBL61680 Ki = 925.0 nM 6.03
CHEMBL65144 Ki = 945.0 nM 6.03
CHEMBL65228 Ki = 1575.0 nM 5.80
CHEMBL303312 Ki = 3250.0 nM 5.49
CHEMBL61014 Ki = 3300.0 nM 5.48
CHEMBL304427 Ki = 3680.0 nM 5.43
CHEMBL65556 Ki = 4205.0 nM 5.38
CHEMBL62650 Ki = 4400.0 nM 5.36
CHEMBL65199 Ki = 5500.0 nM 5.26
CHEMBL61678 Ki = 5500.0 nM 5.26
CHEMBL65089 Ki = 9000.0 nM 5.05
CHEMBL62822 Ki = 11750.0 nM 4.93
CHEMBL302863 Ki = 15770.0 nM 4.80
CHEMBL62322 Ki = 16900.0 nM 4.77
CHEMBL62503 Ki = 20500.0 nM 4.69
CHEMBL65377 Ki = 20700.0 nM 4.68
CHEMBL65715 Ki = 23500.0 nM 4.63
CHEMBL291432 Ki = 25000.0 nM 4.60
CHEMBL61627 Ki = 43750.0 nM 4.36