Assay Detail
Functional
CHEMBL760254
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor gamma-Gal4 chimeric receptor in transfected CV-1 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL2459) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.08 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124079 | — | — | 1 | 7.92 |
| CHEMBL124842 | — | — | 1 | 6.40 |
| CHEMBL340011 | — | — | 1 | 6.06 |
| CHEMBL125230 | — | — | 1 | 6.00 |
| CHEMBL278590 | GSK-9578 | — | 1 | 5.82 |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | 4.26 |
| CHEMBL981 | FENOFIBRIC ACID | 4.0 | 1 | - |
| CHEMBL683 | CLOFIBRIC ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124079 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL124842 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL340011 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL125230 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL278590 | GSK-9578 | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL264374 | BEZAFIBRATE | EC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL981 | FENOFIBRIC ACID | EC50 | = | 250000.0 | nM | - |
| CHEMBL683 | CLOFIBRIC ACID | EC50 | > | 300000.0 | nM | - |