Assay Detail
Functional
CHEMBL760344
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Effective concentration required to inhibit P24 antigen production in PHA-PBM cells exposed to HIV-1 LAI
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBM |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.31 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 7.40 |
| CHEMBL606941 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL991 | STAVUDINE | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL606941 | — | EC50 | = | 60.0 | nM | 7.22 |