Assay Detail
Functional
CHEMBL760345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro anti-HIV activity in human peripheral blood mononuclear (PBM) cells acutely infected with HIV-1 LAI
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and in vitro anti-human immunodeficiency virus activity of artemisinin (qinghaosu)-related trioxanes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.60 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL2368117 | — | — | 1 | 5.33 |
| CHEMBL301267 | ARTEMOTIL | 2.0 | 1 | 4.38 |
| CHEMBL2368325 | — | — | 1 | 4.30 |
| CHEMBL171407 | — | — | 1 | - |
| CHEMBL2367467 | DEOXOARTEMISININ | — | 1 | - |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2368117 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL301267 | ARTEMOTIL | EC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL2368325 | — | EC50 | = | 50200.0 | nM | 4.30 |
| CHEMBL171407 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2367467 | DEOXOARTEMISININ | EC50 | > | 100000.0 | nM | - |
| CHEMBL269671 | ARTEMISININ | EC50 | > | 100000.0 | nM | - |