Assay Detail
Binding
CHEMBL760359
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Inhibition of protein kinase C was evaluated as Inhibitory concentration
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Protein kinase C, PKC; classical (CHEMBL2097168) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.31 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317961 | — | — | 1 | 8.39 |
| CHEMBL421565 | — | — | 1 | 8.12 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.05 |
| CHEMBL1202926 | — | — | 1 | 8.01 |
| CHEMBL319788 | — | — | 1 | 8.00 |
| CHEMBL316918 | — | — | 1 | 7.85 |
| CHEMBL99825 | — | — | 1 | 7.82 |
| CHEMBL327723 | — | — | 1 | 7.78 |
| CHEMBL1202928 | — | — | 1 | 7.64 |
| CHEMBL1202927 | — | — | 1 | 7.38 |
| CHEMBL317792 | — | — | 1 | 7.33 |
| CHEMBL327509 | — | — | 1 | 7.31 |
| CHEMBL269264 | — | — | 1 | 7.12 |
| CHEMBL96002 | — | — | 1 | 7.00 |
| CHEMBL330160 | — | — | 1 | 6.96 |
| CHEMBL328399 | — | — | 1 | 6.87 |
| CHEMBL95592 | — | — | 1 | 6.81 |
| CHEMBL317987 | — | — | 1 | 6.68 |
| CHEMBL95613 | — | — | 1 | 6.57 |
| CHEMBL97522 | — | — | 1 | 6.40 |
| CHEMBL319787 | — | — | 1 | 6.35 |
| CHEMBL100084 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317961 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL421565 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1202926 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL319788 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL316918 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL99825 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL327723 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL1202928 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1202927 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL317792 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL327509 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL269264 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL96002 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL330160 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL328399 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL95592 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL317987 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL95613 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL97522 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL319787 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL100084 | — | IC50 | = | 540.0 | nM | 6.27 |