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Assay Detail

CHEMBL760423

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Binding
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
ChEMBL ↗
97
Total Activities
97
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Oxytocin receptor (CHEMBL3996) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Orally active, nonpeptide oxytocin antagonists.
Evans BE, Leighton JL, Rittle KE, Gilbert KF, Lundell GF, Gould NP, Hobbs DW, DiPardo RM, Veber DF, Pettibone DJ.
J Med Chem (1992) 35 : 3919 -3927
PubMed 1331449 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 97 5.58 6.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL126999 — — 1 6.47
CHEMBL130695 — — 1 6.46
CHEMBL340153 — — 1 6.34
CHEMBL338318 — — 1 6.33
CHEMBL339302 — — 1 6.25
CHEMBL127016 — — 1 6.25
CHEMBL125847 — — 1 6.23
CHEMBL129104 — — 1 6.22
CHEMBL338235 — — 1 6.20
CHEMBL129513 — — 1 6.12
CHEMBL339681 — — 1 6.11
CHEMBL127049 — — 1 6.11
CHEMBL338409 — — 1 6.05
CHEMBL340237 — — 1 6.01
CHEMBL126709 — — 1 6.00
CHEMBL129268 — — 1 5.96
CHEMBL126717 — — 1 5.96
CHEMBL338757 — — 1 5.92
CHEMBL127063 — — 1 5.89
CHEMBL419422 — — 1 5.85
CHEMBL126962 — — 1 5.75
CHEMBL341274 — — 1 5.72
CHEMBL130351 — — 1 5.72
CHEMBL340102 — — 1 5.70
CHEMBL127118 — — 1 5.66
CHEMBL339093 — — 1 5.66
CHEMBL338170 — — 1 5.64
CHEMBL129498 — — 1 5.64
CHEMBL341267 — — 1 5.62
CHEMBL338336 — — 1 5.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL126999 — IC50 = 340.0 nM 6.47
CHEMBL130695 — IC50 = 350.0 nM 6.46
CHEMBL340153 — IC50 = 460.0 nM 6.34
CHEMBL338318 — IC50 = 470.0 nM 6.33
CHEMBL339302 — IC50 = 560.0 nM 6.25
CHEMBL127016 — IC50 = 560.0 nM 6.25
CHEMBL125847 — IC50 = 590.0 nM 6.23
CHEMBL129104 — IC50 = 600.0 nM 6.22
CHEMBL338235 — IC50 = 630.0 nM 6.20
CHEMBL129513 — IC50 = 760.0 nM 6.12
CHEMBL339681 — IC50 = 780.0 nM 6.11
CHEMBL127049 — IC50 = 770.0 nM 6.11
CHEMBL338409 — IC50 = 890.0 nM 6.05
CHEMBL340237 — IC50 = 980.0 nM 6.01
CHEMBL126709 — IC50 = 1000.0 nM 6.00
CHEMBL129268 — IC50 = 1100.0 nM 5.96
CHEMBL126717 — IC50 = 1100.0 nM 5.96
CHEMBL338757 — IC50 = 1200.0 nM 5.92
CHEMBL127063 — IC50 = 1300.0 nM 5.89
CHEMBL419422 — IC50 = 1400.0 nM 5.85
CHEMBL126962 — IC50 = 1800.0 nM 5.75
CHEMBL341274 — IC50 = 1900.0 nM 5.72
CHEMBL130351 — IC50 = 1900.0 nM 5.72
CHEMBL340102 — IC50 = 2000.0 nM 5.70
CHEMBL339093 — IC50 = 2200.0 nM 5.66
CHEMBL127118 — IC50 = 2200.0 nM 5.66
CHEMBL338170 — IC50 = 2300.0 nM 5.64
CHEMBL129498 — IC50 = 2300.0 nM 5.64
CHEMBL341267 — IC50 = 2400.0 nM 5.62
CHEMBL338336 — IC50 = 2500.0 nM 5.60
CHEMBL126371 — IC50 = 3000.0 nM 5.52
CHEMBL126565 — IC50 = 3000.0 nM 5.52
CHEMBL340589 — IC50 = 3000.0 nM 5.52
CHEMBL269624 — IC50 = 3400.0 nM 5.47
CHEMBL340920 — IC50 = 3400.0 nM 5.47
CHEMBL125748 — IC50 = 3700.0 nM 5.43
CHEMBL338324 — IC50 = 3900.0 nM 5.41
CHEMBL341490 — IC50 = 4000.0 nM 5.40
CHEMBL341077 — IC50 = 5000.0 nM 5.30
CHEMBL434825 — IC50 = 5400.0 nM 5.27
CHEMBL127117 — IC50 = 5700.0 nM 5.24
CHEMBL126195 — IC50 = 6000.0 nM 5.22
CHEMBL129581 — IC50 = 6200.0 nM 5.21
CHEMBL126824 — IC50 = 6200.0 nM 5.21
CHEMBL340465 — IC50 = 6500.0 nM 5.19
CHEMBL129246 — IC50 = 6400.0 nM 5.19
CHEMBL341108 — IC50 = 7100.0 nM 5.15
CHEMBL128978 — IC50 = 7600.0 nM 5.12
CHEMBL340588 — IC50 = 7600.0 nM 5.12
CHEMBL126708 — IC50 = 8500.0 nM 5.07