Assay Detail
Binding
CHEMBL760427
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.88 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112249 | — | — | 1 | 8.66 |
| CHEMBL2112248 | — | — | 1 | 8.22 |
| CHEMBL2112250 | — | — | 1 | 8.08 |
| CHEMBL435021 | — | — | 1 | 8.08 |
| CHEMBL2112247 | — | — | 1 | 8.00 |
| CHEMBL338018 | — | — | 1 | 7.89 |
| CHEMBL338308 | — | — | 1 | 7.82 |
| CHEMBL1790937 | — | — | 1 | 7.82 |
| CHEMBL2370623 | — | — | 1 | 7.82 |
| CHEMBL127686 | — | — | 1 | 7.75 |
| CHEMBL1790938 | — | — | 1 | 7.75 |
| CHEMBL2112651 | — | — | 1 | 7.70 |
| CHEMBL126765 | — | — | 1 | 7.60 |
| CHEMBL340204 | — | — | 1 | 7.35 |
| CHEMBL419793 | — | — | 1 | 7.19 |
| CHEMBL405289 | — | — | 1 | 7.14 |
| CHEMBL2112654 | — | — | 1 | 7.06 |
| CHEMBL338294 | — | — | 1 | 6.80 |
| CHEMBL340479 | — | — | 1 | 6.72 |
| CHEMBL338020 | — | — | 1 | 6.72 |
| CHEMBL339118 | — | — | 1 | 6.70 |
| CHEMBL339450 | — | — | 1 | 6.66 |
| CHEMBL129733 | — | — | 1 | 6.47 |
| CHEMBL2112655 | — | — | 1 | 6.39 |
| CHEMBL127056 | — | — | 1 | 6.27 |
| CHEMBL129089 | — | — | 1 | 6.18 |
| CHEMBL338981 | — | — | 1 | 6.17 |
| CHEMBL2112650 | — | — | 1 | 6.03 |
| CHEMBL339493 | — | — | 1 | 5.92 |
| CHEMBL436397 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112249 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2112248 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2112250 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL435021 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL2112247 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL338018 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL338308 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1790937 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2370623 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL127686 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1790938 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2112651 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL126765 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL340204 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL419793 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL405289 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL2112654 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL338294 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL338020 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL340479 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL339118 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL339450 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL129733 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2112655 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL127056 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL129089 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL338981 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL2112650 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL339493 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL436397 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL339452 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL129414 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL52813 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL338221 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2112656 | — | IC50 | = | 30000.0 | nM | 4.52 |