Assay Detail
Functional
CHEMBL760448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
94
Total Activities
93
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a novel series of platelet activating factor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 94 | 7.88 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63100 | — | — | 1 | 9.22 |
| CHEMBL64057 | — | — | 1 | 9.10 |
| CHEMBL539673 | — | — | 1 | 9.00 |
| CHEMBL64691 | — | — | 1 | 9.00 |
| CHEMBL64214 | — | — | 1 | 9.00 |
| CHEMBL61416 | — | — | 1 | 9.00 |
| CHEMBL60081 | — | — | 1 | 8.96 |
| CHEMBL64428 | — | — | 1 | 8.92 |
| CHEMBL305372 | — | — | 1 | 8.89 |
| CHEMBL293662 | — | — | 1 | 8.85 |
| CHEMBL293906 | — | — | 1 | 8.85 |
| CHEMBL64464 | — | — | 1 | 8.82 |
| CHEMBL62497 | — | — | 1 | 8.80 |
| CHEMBL62830 | — | — | 1 | 8.80 |
| CHEMBL439937 | — | — | 1 | 8.80 |
| CHEMBL291372 | — | — | 1 | 8.74 |
| CHEMBL64636 | — | — | 1 | 8.72 |
| CHEMBL63383 | — | — | 1 | 8.72 |
| CHEMBL417563 | — | — | 1 | 8.70 |
| CHEMBL293457 | — | — | 1 | 8.66 |
| CHEMBL293259 | — | — | 1 | 8.62 |
| CHEMBL292860 | — | — | 1 | 8.59 |
| CHEMBL64860 | — | — | 1 | 8.52 |
| CHEMBL60359 | — | — | 1 | 8.52 |
| CHEMBL302696 | — | — | 1 | 8.47 |
| CHEMBL64035 | — | — | 1 | 8.47 |
| CHEMBL62815 | — | — | 1 | 8.47 |
| CHEMBL64621 | — | — | 1 | 8.44 |
| CHEMBL62942 | — | — | 1 | 8.36 |
| CHEMBL64445 | — | — | 1 | 8.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63100 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL64057 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL64691 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL64214 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL61416 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL539673 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL60081 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL64428 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL305372 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL293662 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL293906 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL64464 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL439937 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL62830 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL62497 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL291372 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL64636 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL63383 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL417563 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL293457 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL293259 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL292860 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL64860 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL60359 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL62815 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL64035 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL302696 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL64621 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL62942 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL64445 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL64472 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL304879 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL293862 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL62983 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL418125 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL302683 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL62219 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL29067 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL60996 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL303357 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL442170 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL62722 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL60477 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL64034 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL293642 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL64125 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL64882 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL305145 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL293641 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL62308 | — | Ki | = | 12.5 | nM | 7.90 |