Assay Detail
Binding
CHEMBL760449
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Inhibition of [3H]PAF binding to rabbit platelet membrane
15
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Design and modeling of new platelet-activating factor antagonists. 1. Synthesis and biological activity of 1,4-bis(3',4',5'-trimethoxybenzoyl)-2-[[(substituted carbonyl and carbamoyl)oxy]methyl]piperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.60 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6203 | — | — | 3 | 7.30 |
| CHEMBL258053 | — | — | 1 | 7.16 |
| CHEMBL6270 | — | — | 3 | 7.05 |
| CHEMBL269132 | — | — | 1 | 6.75 |
| CHEMBL514432 | GINKOLIDE B | — | 1 | 6.75 |
| CHEMBL268596 | — | — | 3 | 6.52 |
| CHEMBL6217 | — | — | 1 | 6.40 |
| CHEMBL269131 | — | — | 1 | 6.17 |
| CHEMBL269340 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6203 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL258053 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL6270 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL269132 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL514432 | GINKOLIDE B | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL6270 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL6270 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL268596 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL268596 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL6217 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL268596 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL6203 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL6203 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL269131 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL269340 | — | EC50 | = | 700.0 | nM | 6.16 |