Assay Detail
Binding
CHEMBL760450
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PAF receptor binding to rabbit platelet plasma membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.94 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297624 | — | — | 1 | 7.70 |
| CHEMBL56856 | — | — | 1 | 6.70 |
| CHEMBL291668 | — | — | 1 | 6.30 |
| CHEMBL291515 | — | — | 1 | 5.96 |
| CHEMBL56800 | — | — | 1 | 5.96 |
| CHEMBL57542 | — | — | 1 | 5.35 |
| CHEMBL418309 | GALGRAVIN | — | 1 | 5.35 |
| CHEMBL56917 | — | — | 1 | 5.35 |
| CHEMBL291332 | — | — | 1 | 4.82 |
| CHEMBL301484 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297624 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL56856 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL291668 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL291515 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL56800 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL57542 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL418309 | GALGRAVIN | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL56917 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL291332 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL301484 | — | IC50 | > | 3000.0 | nM | - |