Assay Detail
Binding
CHEMBL760476
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Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 50 mM phosphate
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Spleen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.55 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352454 | — | — | 1 | 9.80 |
| CHEMBL79784 | — | — | 1 | 7.10 |
| CHEMBL310364 | — | — | 1 | 6.82 |
| CHEMBL351815 | — | — | 1 | 6.82 |
| CHEMBL285627 | — | — | 1 | 6.80 |
| CHEMBL311300 | PELDESINE | 2.0 | 1 | 6.72 |
| CHEMBL354926 | — | — | 1 | 6.72 |
| CHEMBL310202 | — | — | 1 | 6.68 |
| CHEMBL159908 | — | — | 1 | 6.66 |
| CHEMBL160043 | — | — | 1 | 6.60 |
| CHEMBL349615 | — | — | 1 | 6.57 |
| CHEMBL159960 | — | — | 1 | 6.57 |
| CHEMBL82087 | — | — | 1 | 6.56 |
| CHEMBL351205 | — | — | 1 | 6.50 |
| CHEMBL79410 | — | — | 1 | 6.42 |
| CHEMBL162751 | — | — | 1 | 6.18 |
| CHEMBL159471 | — | — | 1 | 6.13 |
| CHEMBL309679 | — | — | 1 | 5.70 |
| CHEMBL81731 | — | — | 1 | 5.64 |
| CHEMBL81966 | — | — | 1 | 5.60 |
| CHEMBL158599 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352454 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL79784 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL310364 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL351815 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL285627 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL311300 | PELDESINE | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL354926 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL310202 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL159908 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL160043 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL349615 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL159960 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL82087 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL351205 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL79410 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL162751 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL159471 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL309679 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL81731 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL81966 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL158599 | — | IC50 | = | 10000.0 | nM | 5.00 |