Assay Detail
Binding
CHEMBL760481
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PNP activity in human RBC
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Nucleosides. 5. Synthesis of guanine and formycin B derivatives as potential inhibitors of purine nucleoside phosphorylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.03 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8230 | — | — | 1 | 6.70 |
| CHEMBL603291 | — | — | 1 | 6.35 |
| CHEMBL8040 | 8-AMINOGUANINE | — | 1 | 6.10 |
| CHEMBL606329 | — | — | 1 | 5.16 |
| CHEMBL376474 | — | — | 1 | 4.87 |
| CHEMBL274150 | — | — | 1 | 4.82 |
| CHEMBL223508 | — | — | 1 | 4.73 |
| CHEMBL8092 | — | — | 1 | 4.64 |
| CHEMBL603290 | — | — | 1 | 4.58 |
| CHEMBL606113 | — | — | 1 | 4.43 |
| CHEMBL606330 | — | — | 1 | 4.03 |
| CHEMBL3144008 | — | — | 1 | 4.00 |
| CHEMBL3144020 | — | — | 1 | - |
| CHEMBL267803 | — | — | 1 | - |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8230 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL603291 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL8040 | 8-AMINOGUANINE | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL606329 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL376474 | — | Ki | = | 13400.0 | nM | 4.87 |
| CHEMBL274150 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL223508 | — | Ki | = | 18700.0 | nM | 4.73 |
| CHEMBL8092 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL603290 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL606113 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL606330 | — | Ki | = | 93000.0 | nM | 4.03 |
| CHEMBL3144008 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL3144020 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL267803 | — | Ki | = | 170000.0 | nM | - |
| CHEMBL184 | ACYCLOVIR | Ki | = | 180000.0 | nM | - |