Assay Detail
Binding
CHEMBL760630
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Compound was tested for inhibition of human secretory pancreatic Phospholipase A2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.36 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436456 | — | — | 1 | 7.21 |
| CHEMBL148674 | VARESPLADIB | 2.0 | 1 | 6.64 |
| CHEMBL357979 | — | — | 1 | 6.44 |
| CHEMBL355944 | — | — | 1 | 6.24 |
| CHEMBL346196 | — | — | 1 | 6.12 |
| CHEMBL148861 | — | — | 1 | 5.96 |
| CHEMBL357804 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436456 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL148674 | VARESPLADIB | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL357979 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL355944 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL346196 | — | IC50 | = | 761.0 | nM | 6.12 |
| CHEMBL148861 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL357804 | — | IC50 | = | 1200.0 | nM | 5.92 |