Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL148674

VARESPLADIB
🧪 Phase II
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
🧪 Phase II
CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL148674
Name VARESPLADIB
Phase Phase II
Structure Type MOL
InChI Key BHLXTPHDSZUFHR-UHFFFAOYSA-N

Known Names

LY-315920 LY315920 Varepladib Varespladib Varespladib sodium
17
Targets
51
Activities
1
Assay Types
1
PK Parameters
20
Publications
5
Known Names
3
Indications
1
Mechanisms

Molecular Properties

380.4
MW (Da)
2.38
ALogP
5
HBA
2
HBD
111.6
PSA (Ų)
0.46
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product
USAN Stem -pladib
USAN Year 2002

Extended Properties

Molecular Formula C21H20N2O5
MW 380.40
Aromatic Rings 3
Heavy Atoms 28
NP-Likeness -0.68

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Phospholipase A2 group IIA inhibitor INHIBITOR Phospholipase A2, membrane associated ✓ ✓

Indications

Anemia, Sickle Cell Coronary Disease Severe Acute Respiratory Syndrome

Activity Summary

IC50 51 meas. best 8.15

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Phospholipase A2, membrane associated
CHEMBL3474
 IC50 8.15 7.7289 7.0 9
Unchecked
CHEMBL612545
 IC50 8.05 7.485 9.0 2
Group 10 secretory phospholipase A2
CHEMBL4342
 IC50 7.39 7.135 41.0 6
Phospholipase A2, major isoenzyme
CHEMBL4715
 IC50 7.32 7.32 48.0 2
Group IIE secretory phospholipase A2
CHEMBL2154
 IC50 7.3 7.3 50.0 2
85/88 kDa calcium-independent phospholipase A2
CHEMBL3213
 IC50 7.25 6.4125 56.0 8
Group IID secretory phospholipase A2
CHEMBL4281
 IC50 7.22 7.22 60.0 1
Phospholipase A2, membrane associated
CHEMBL5761
 IC50 7.16 7.16 70.0 2
Group IIE secretory phospholipase A2
CHEMBL4201
 IC50 7.12 7.12 75.0 2
Group 10 secretory phospholipase A2
CHEMBL4200
 IC50 7.12 7.12 75.0 2
Secretory phospholipase A2
CHEMBL4524005
 IC50 6.94 6.91 114.0 2
Phospholipase A2 group V
CHEMBL4323
 IC50 6.91 6.5033 124.0 3
Group IIF secretory phospholipase A2
CHEMBL4278
 IC50 6.89 6.89 130.0 1
Phospholipase A2
CHEMBL4378
 IC50 6.85 6.85 140.0 2
Phospholipase A2
CHEMBL4426
 IC50 6.64 6.38 228.0 4
Group IID secretory phospholipase A2
CHEMBL5537
 IC50 6.37 6.37 430.0 1
Phospholipase A2 group V
CHEMBL4167
 IC50 6.12 6.12 750.0 2

Pharmacokinetic Data

Parameter Value Units Species
Fu 0.125 - Homo sapiens

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Phospholipase A2, membrane associated IC50 = 7.0 nM 8.15 Inhibition of human nonpancreatic secretory Phospholipase A2 through DOC/PC assa... 8978844
Phospholipase A2, membrane associated IC50 = 7.0 nM 8.15 Inhibitory concentration against human nonpancreatic secretory phospholipase A2 15689175
Phospholipase A2, membrane associated IC50 = 9.0 nM 8.05 Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic... 8978844
Unchecked IC50 = 9.0 nM 8.05 Inhibition of recombinant human sPLA2 after 30 mins microtiter plate assay 26935940
Phospholipase A2, membrane associated IC50 = 9.0 nM 8.05 Inhibition of human group IIA phospholipase A2 incubated for 1 hrs by scintillat... 33764065
Phospholipase A2, membrane associated IC50 = 12.0 nM 7.92 Inhibition of recombinant human sPLA2-2A expressed in Escherichia coli BL21(DE3)... 30034585
Phospholipase A2, membrane associated IC50 = 13.0 nM 7.89 Inhibitory concentration against human nonpancreatic secretory phospholipase A2 15689175
Phospholipase A2, membrane associated IC50 = 28.0 nM 7.55 Inhibition of recombinant sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-s... 27774123
Group 10 secretory phospholipase A2 IC50 = 41.0 nM 7.39 Inhibition of recombinant human sPLA2-10 expressed in Escherichia coli BL21(DE3)... 30034585
Group 10 secretory phospholipase A2 IC50 = 41.0 nM 7.39 Inhibition of recombinant sPLA2-10 (unknown origin) using 1-palmitoyl-2-oleoyl-s... 27774123
Phospholipase A2, major isoenzyme IC50 = 48.0 nM 7.32 Compound was tested for inhibition of porcine secretory pancreatic PLA2 8978844
Phospholipase A2, major isoenzyme IC50 = 48.0 nM 7.32 Inhibition of pig group IB phospholipase A2 incubated for 1 hrs by scintillation... 33764065
Group IIE secretory phospholipase A2 IC50 = 50.0 nM 7.3 Inhibition of human recombinant sPLA2 G2E 16686528
Group IIE secretory phospholipase A2 IC50 = 50.0 nM 7.3 Inhibition of human group2E phospholipase A2 fluorimetric assay 18605714
85/88 kDa calcium-independent phospholipase A2 IC50 = 56.0 nM 7.25 Inhibition of human recombinant calcium-independent PLA2 using PAPC as substrate... 30615445
Group IID secretory phospholipase A2 IC50 = 60.0 nM 7.22 Inhibition of human group2D phospholipase A2 by [3H]oleic acid-labeled Escherich... 18605714
Phospholipase A2, membrane associated IC50 = 70.0 nM 7.16 Inhibition of mouse recombinant sPLA2 G2A 16686528
Phospholipase A2, membrane associated IC50 = 70.0 nM 7.16 Inhibition of mouse group2A phospholipase A2 fluorimetric assay 18605714
Group 10 secretory phospholipase A2 IC50 = 75.0 nM 7.12 Inhibition of human group2X phospholipase A2 fluorimetric assay 18605714
Group 10 secretory phospholipase A2 IC50 = 75.0 nM 7.12 Inhibition of mouse recombinant sPLA2 G10 16686528

Literature References

PubMed DOI Target Context # Activities
30615445 10.1021/acs.jmedchem.8b01568 85/88 kDa calcium-independent phospholipase A2 16
30615445 10.1021/acs.jmedchem.8b01568 Secretory phospholipase A2 10
17973469 10.1021/jm070385x Unchecked 5
- 10.6019/CHEMBL3301361 ADMET 4
8978844 10.1021/jm960487f Cavia porcellus 2
8978844 10.1021/jm960487f Phospholipase A2, membrane associated 2
18605714 10.1021/jm800422v Group 10 secretory phospholipase A2 2
18605714 10.1021/jm800422v Phospholipase A2 group V 2
18605714 10.1021/jm800422v Group IIE secretory phospholipase A2 2
18605714 10.1021/jm800422v Group IID secretory phospholipase A2 2
18605714 10.1021/jm800422v Phospholipase A2, membrane associated 2
18605714 10.1021/jm800422v Phospholipase A2 2
8978844 10.1021/jm960487f Unchecked 2
30034585 10.1021/acsmedchemlett.7b00505 Group 10 secretory phospholipase A2 2
16686528 10.1021/jm060136t Group 10 secretory phospholipase A2 2
16686528 10.1021/jm060136t Phospholipase A2 group V 2
16686528 10.1021/jm060136t Group IIE secretory phospholipase A2 2
16686528 10.1021/jm060136t Phospholipase A2, membrane associated 2
16686528 10.1021/jm060136t Phospholipase A2 2
15689175 10.1021/jm0401309 Phospholipase A2, membrane associated 2

Data from ChEMBL 36 via Core Engine