Assay Detail
Binding
CHEMBL862126
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Inhibition of mouse recombinant sPLA2 G2A
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Phospholipase A2, membrane associated (CHEMBL5761) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.07 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208315 | — | — | 1 | 7.30 |
| CHEMBL148674 | VARESPLADIB | 2.0 | 1 | 7.16 |
| CHEMBL346196 | — | — | 1 | 6.90 |
| CHEMBL208429 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208315 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL148674 | VARESPLADIB | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL346196 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL208429 | — | IC50 | = | 125.0 | nM | 6.90 |