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Target Snapshot

CHEMBL5761 Target Snapshot

Phospholipase A2, membrane associated · SINGLE PROTEIN · Mus musculus

37Compounds
8Assays
0Approved Drugs
32.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P31482. Use UniProt P31482 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P31482 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Phospholipase A2, membrane associated as ChEMBL target CHEMBL5761, mapped to UniProt P31482. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Phospholipase A2, membrane associated
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL5761
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P31482
Phospholipase A2, membrane associated
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Phospholipase A2, membrane associated is the right protein anchor across sources, using UniProt P31482 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPhospholipase A2, membrane associated
UniProt AccessionP31482
Component TypeProtein
Sequence Length146 aa

Phospholipase A2, membrane associated

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Phospholipase A2, membrane associated, mapped to UniProt P31482. Sequence length is 146 aa.

Mapped IDP31482
Review namePhospholipase A2, membrane associated
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC5032.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5172164 8.0 IC50 10.0 Preclinical
CHEMBL444450 7.52 IC50 30.0 Preclinical
CHEMBL515637 7.52 IC50 30.0 Preclinical
CHEMBL514841 7.47 IC50 34.0 Preclinical
CHEMBL208315 7.3 IC50 50.0 Preclinical
CHEMBL148649 7.22 IC50 60.0 Preclinical
CHEMBL485601 7.22 IC50 60.0 Preclinical
CHEMBL514692 7.22 IC50 60.0 Preclinical
CHEMBL3769794 7.17 IC50 68.0 Preclinical
CHEMBL148674 7.16 IC50 70.0 Clinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
5
6.5
9
7.0
2
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

8
Total Assays
16
Tested Compounds
1
Assay Types
Binding — 8 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 7 15 7.2
assay format 1 1 8.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine