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Assay Detail

CHEMBL829138

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against human nonpancreatic secretory phospholipase A2
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Phospholipase A2, membrane associated (CHEMBL3474)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbocyclic[g]indole inhibitors of human nonpancreatic s-PLA2.
Sawyer JS, Beight DW, Smith EC, Snyder DW, Chastain MK, Tielking RL, Hartley LW, Carlson DG.
J Med Chem (2005) 48 : 893 -896
PubMed 15689175 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.44 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL180576 1 8.15
CHEMBL179118 1 8.05
CHEMBL179966 1 8.00
CHEMBL361552 1 8.00
CHEMBL425869 1 8.00
CHEMBL425696 1 7.96
CHEMBL435488 1 7.96
CHEMBL148674 VARESPLADIB 2.0 1 7.89
CHEMBL179658 1 7.89
CHEMBL433767 1 7.14
CHEMBL178675 1 7.09
CHEMBL178405 1 7.00
CHEMBL179309 1 6.97
CHEMBL425697 1 6.97
CHEMBL180063 1 6.96
CHEMBL178187 1 6.88
CHEMBL178260 1 6.83
CHEMBL178140 1 6.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL180576 IC50 = 7.0 nM 8.15
CHEMBL179118 IC50 = 9.0 nM 8.05
CHEMBL179966 IC50 = 10.0 nM 8.00
CHEMBL361552 IC50 = 10.0 nM 8.00
CHEMBL425869 IC50 = 10.0 nM 8.00
CHEMBL425696 IC50 = 11.0 nM 7.96
CHEMBL435488 IC50 = 11.0 nM 7.96
CHEMBL148674 VARESPLADIB IC50 = 13.0 nM 7.89
CHEMBL179658 IC50 = 13.0 nM 7.89
CHEMBL433767 IC50 = 73.0 nM 7.14
CHEMBL178675 IC50 = 82.0 nM 7.09
CHEMBL178405 IC50 = 100.0 nM 7.00
CHEMBL179309 IC50 = 108.0 nM 6.97
CHEMBL425697 IC50 = 106.0 nM 6.97
CHEMBL180063 IC50 = 109.0 nM 6.96
CHEMBL178187 IC50 = 132.0 nM 6.88
CHEMBL178260 IC50 = 148.0 nM 6.83
CHEMBL178140 IC50 = 806.0 nM 6.09