Assay Detail
Binding
CHEMBL828100
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Inhibitory concentration against human nonpancreatic secretory phospholipase A2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Phospholipase A2, membrane associated (CHEMBL3474) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Carbocyclic[g]indole inhibitors of human nonpancreatic s-PLA2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.14 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180576 | — | — | 1 | 8.52 |
| CHEMBL425696 | — | — | 1 | 8.40 |
| CHEMBL361552 | — | — | 1 | 8.22 |
| CHEMBL148674 | VARESPLADIB | 2.0 | 1 | 8.15 |
| CHEMBL179658 | — | — | 1 | 8.15 |
| CHEMBL425869 | — | — | 1 | 7.80 |
| CHEMBL435488 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180576 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL425696 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL361552 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL148674 | VARESPLADIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL179658 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL425869 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL435488 | — | IC50 | = | 17.0 | nM | 7.77 |