Assay Detail
Binding
CHEMBL990836
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Inhibition of human group2X phospholipase A2 fluorimetric assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.30 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477548 | — | — | 1 | 8.15 |
| CHEMBL514705 | — | — | 1 | 8.00 |
| CHEMBL514656 | — | — | 1 | 7.96 |
| CHEMBL474874 | — | — | 1 | 7.85 |
| CHEMBL514692 | — | — | 1 | 7.82 |
| CHEMBL515637 | — | — | 1 | 7.70 |
| CHEMBL148649 | — | — | 1 | 7.66 |
| CHEMBL477549 | — | — | 1 | 7.52 |
| CHEMBL506485 | — | — | 1 | 7.52 |
| CHEMBL504813 | — | — | 1 | 7.30 |
| CHEMBL477794 | — | — | 1 | 7.16 |
| CHEMBL148674 | VARESPLADIB | 2.0 | 1 | 7.12 |
| CHEMBL477156 | — | — | 1 | 7.10 |
| CHEMBL446349 | — | — | 1 | 7.05 |
| CHEMBL477157 | — | — | 1 | 6.85 |
| CHEMBL475071 | — | — | 1 | 6.50 |
| CHEMBL514846 | — | — | 1 | 6.27 |
| CHEMBL514841 | — | — | 1 | 5.82 |
| CHEMBL479251 | — | — | 1 | - |
| CHEMBL332993 | — | — | 1 | - |
| CHEMBL478820 | — | — | 1 | - |
| CHEMBL517821 | — | — | 1 | - |
| CHEMBL478821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477548 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL514705 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL514656 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL474874 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL514692 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL515637 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL148649 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL477549 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL506485 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL504813 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL477794 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL148674 | VARESPLADIB | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL477156 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL446349 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL477157 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL475071 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL514846 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL514841 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL479251 | — | IC50 | > | 21.0 | nM | - |
| CHEMBL332993 | — | IC50 | > | 1600.0 | nM | - |
| CHEMBL478820 | — | IC50 | > | 1600.0 | nM | - |
| CHEMBL517821 | — | IC50 | > | 1600.0 | nM | - |
| CHEMBL478821 | — | IC50 | > | 1600.0 | nM | - |