Assay Detail
Binding
CHEMBL761440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Phospholipase A2, membrane associated (CHEMBL3474) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 7.15 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436456 | — | — | 1 | 8.40 |
| CHEMBL345488 | — | — | 1 | 8.22 |
| CHEMBL347957 | — | — | 1 | 8.22 |
| CHEMBL357979 | — | — | 1 | 8.22 |
| CHEMBL356606 | — | — | 1 | 8.22 |
| CHEMBL345986 | — | — | 1 | 8.15 |
| CHEMBL433701 | — | — | 1 | 8.10 |
| CHEMBL347748 | — | — | 1 | 8.10 |
| CHEMBL148674 | VARESPLADIB | 2.0 | 1 | 8.05 |
| CHEMBL148795 | — | — | 1 | 8.05 |
| CHEMBL355944 | — | — | 1 | 8.05 |
| CHEMBL357804 | — | — | 1 | 8.05 |
| CHEMBL422667 | — | — | 1 | 8.00 |
| CHEMBL359005 | — | — | 1 | 7.96 |
| CHEMBL346196 | — | — | 1 | 7.96 |
| CHEMBL148649 | — | — | 1 | 7.96 |
| CHEMBL423219 | — | — | 1 | 7.82 |
| CHEMBL358872 | — | — | 1 | 7.60 |
| CHEMBL358163 | — | — | 1 | 7.55 |
| CHEMBL148452 | — | — | 1 | 7.52 |
| CHEMBL148861 | — | — | 1 | 7.37 |
| CHEMBL358155 | — | — | 1 | 7.34 |
| CHEMBL146924 | — | — | 1 | 7.31 |
| CHEMBL347052 | — | — | 1 | 7.09 |
| CHEMBL149952 | — | — | 1 | 7.09 |
| CHEMBL148665 | — | — | 1 | 7.02 |
| CHEMBL149434 | — | — | 1 | 6.91 |
| CHEMBL345987 | — | — | 1 | 6.85 |
| CHEMBL149206 | — | — | 1 | 6.84 |
| CHEMBL149779 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436456 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL345488 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL356606 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL347957 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL357979 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL345986 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL433701 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL347748 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL148674 | VARESPLADIB | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL148795 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL355944 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL357804 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL422667 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL148649 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL359005 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL346196 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL423219 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL358872 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL358163 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL148452 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL148861 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL358155 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL146924 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL149952 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL347052 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL148665 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL149434 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL345987 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL149206 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL149779 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL345275 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL148807 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL359148 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL359308 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL445135 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL430348 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL356133 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL356691 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL434131 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL347543 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL149271 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL345962 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL346641 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL348462 | — | IC50 | > | 100000.0 | nM | - |