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Assay Detail

CHEMBL760652

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Functional
In vitro antimalarial activity against Plasmodium falciparum
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Mechanism-based development of new antimalarials: synthesis of derivatives of artemisinin attached to iron chelators.
Kamchonwongpaisan S, Paitayatat S, Thebtaranonth Y, Wilairat P, Yuthavong Y.
J Med Chem (1995) 38 : 2311 -2316
PubMed 7608896 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.46 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL307261 ARTENIMOL 3.0 1 8.96
CHEMBL306763 1 8.43
CHEMBL77052 1 8.37
CHEMBL75471 1 8.32
CHEMBL269671 ARTEMISININ 3.0 1 8.23
CHEMBL76817 1 8.18
CHEMBL305899 1 8.12
CHEMBL74084 1 8.12
CHEMBL307153 1 8.02
CHEMBL77931 1 7.90
CHEMBL307138 1 7.63
CHEMBL77491 1 7.28
CHEMBL307145 PYROGALLOL -1.0 1 5.25
CHEMBL16300 BENZOHYDROXAMATE 1 4.75
CHEMBL17001 METHYLCAFFEATE 1 4.33
CHEMBL309339 SALICYLHYDROXAMIC ACID 1 -
CHEMBL145 CAFFEIC ACID 3.0 1 -
CHEMBL287556 KOJIC ACID 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL307261 ARTENIMOL IC50 = 1.1 nM 8.96
CHEMBL306763 IC50 = 3.68 nM 8.43
CHEMBL77052 IC50 = 4.25 nM 8.37
CHEMBL75471 IC50 = 4.78 nM 8.32
CHEMBL269671 ARTEMISININ IC50 = 5.82 nM 8.23
CHEMBL76817 IC50 = 6.64 nM 8.18
CHEMBL305899 IC50 = 7.67 nM 8.12
CHEMBL74084 IC50 = 7.65 nM 8.12
CHEMBL307153 IC50 = 9.55 nM 8.02
CHEMBL77931 IC50 = 12.7 nM 7.90
CHEMBL307138 IC50 = 23.64 nM 7.63
CHEMBL77491 IC50 = 52.45 nM 7.28
CHEMBL307145 PYROGALLOL IC50 = 5660.0 nM 5.25
CHEMBL16300 BENZOHYDROXAMATE IC50 = 17600.0 nM 4.75
CHEMBL17001 METHYLCAFFEATE IC50 = 46500.0 nM 4.33
CHEMBL309339 SALICYLHYDROXAMIC ACID IC50 = 107000.0 nM -
CHEMBL145 CAFFEIC ACID IC50 = 122000.0 nM -
CHEMBL287556 KOJIC ACID IC50 = 1580000.0 nM -