Assay Detail
Functional
CHEMBL760654
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In vitro antimalarial activity against Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana Moens ex Trimen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.29 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 6.80 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.72 |
| CHEMBL588619 | CINCHONINE | -1.0 | 1 | 6.66 |
| CHEMBL27076 | — | — | 2 | 6.44 |
| CHEMBL170 | QUININE | 4.0 | 1 | 6.43 |
| CHEMBL26733 | — | — | 1 | 6.42 |
| CHEMBL533841 | CINCHONIDINE | -1.0 | 1 | 6.42 |
| CHEMBL25738 | — | — | 1 | 6.39 |
| CHEMBL26967 | — | — | 1 | 6.29 |
| CHEMBL27022 | — | — | 1 | 6.28 |
| CHEMBL281943 | — | — | 1 | 6.21 |
| CHEMBL284604 | — | — | 1 | 6.00 |
| CHEMBL281262 | — | — | 1 | 6.00 |
| CHEMBL283942 | — | — | 1 | 5.96 |
| CHEMBL611167 | — | — | 1 | 5.96 |
| CHEMBL283243 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1294 | QUINIDINE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL588619 | CINCHONINE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL27076 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL170 | QUININE | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL26733 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL533841 | CINCHONIDINE | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL25738 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL26967 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL27022 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL281943 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL27076 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL284604 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL281262 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL283942 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL611167 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL283243 | — | IC50 | = | 1200.0 | nM | 5.92 |