Assay Detail
Binding
CHEMBL760746
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Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina
19
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design, synthesis and biological activity of beta-carboline-based type-5 phosphodiesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.09 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282515 | — | — | 2 | 6.90 |
| CHEMBL284070 | — | — | 1 | 6.65 |
| CHEMBL32255 | — | — | 1 | 6.60 |
| CHEMBL33518 | — | — | 1 | 6.57 |
| CHEMBL33121 | — | — | 1 | 6.45 |
| CHEMBL418594 | — | — | 1 | 6.45 |
| CHEMBL285737 | — | — | 1 | 6.21 |
| CHEMBL33627 | — | — | 1 | 6.09 |
| CHEMBL286309 | — | — | 1 | 6.07 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 5.90 |
| CHEMBL34802 | — | — | 1 | 5.87 |
| CHEMBL33147 | — | — | 1 | 5.80 |
| CHEMBL286905 | — | — | 1 | 5.79 |
| CHEMBL33381 | — | — | 1 | 5.75 |
| CHEMBL33944 | — | — | 1 | 5.58 |
| CHEMBL30936 | — | — | 1 | 5.53 |
| CHEMBL284594 | — | — | 1 | 5.08 |
| CHEMBL284258 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282515 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL284070 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL32255 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL33518 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL33121 | — | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL418594 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL282515 | — | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL285737 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL33627 | — | IC50 | = | 807.0 | nM | 6.09 |
| CHEMBL286309 | — | IC50 | = | 846.0 | nM | 6.07 |
| CHEMBL779 | TADALAFIL | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL34802 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL33147 | — | IC50 | = | 1601.0 | nM | 5.80 |
| CHEMBL286905 | — | IC50 | = | 1619.0 | nM | 5.79 |
| CHEMBL33381 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL33944 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL30936 | — | IC50 | = | 2966.0 | nM | 5.53 |
| CHEMBL284594 | — | IC50 | = | 8224.0 | nM | 5.08 |
| CHEMBL284258 | — | IC50 | > | 10.0 | nM | - |