Compound Detail
CHEMBL33147
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NC(=O)CCN1CC[C@@H](N2CC(=O)N3[C@H](c4ccc5c(c4)OCO5)c4[nH]c5ccccc5c4C[C@@H]3C2=O)C1
Basic Information
| ChEMBL ID | CHEMBL33147 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CHAPJCSKENISSM-OYBFMBOMSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
515.6
MW (Da)
1.53
ALogP
6
HBA
2
HBD
121.2
PSA (Ų)
0.53
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 8.08 | 8.08 | 8.4 | 1 |
| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A CHEMBL2717 | IC50 | 7.32 | 7.32 | 48.0 | 1 |
| Phosphodiesterase 6 CHEMBL2097163 | IC50 | 5.8 | 5.8 | 1601.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 8.4 | nM | 8.08 | Inhibitory activity against phosphodiesterase 5 (PDE5) obtained from human corpu... | 12668004 |
| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | IC50 | = | 48.0 | nM | 7.32 | Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombina... | 12668004 |
| Phosphodiesterase 6 | IC50 | = | 1601.0 | nM | 5.8 | Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or b... | 12668004 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12668004 | 10.1016/s0960-894x(03)00159-8 | cGMP-specific 3',5'-cyclic phosphodiesterase | 2 |
| 12668004 | 10.1016/s0960-894x(03)00159-8 | Phosphodiesterase 6 | 1 |
| 12668004 | 10.1016/s0960-894x(03)00159-8 | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | 1 |
| 12668004 | 10.1016/s0960-894x(03)00159-8 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine