Assay Detail
Binding
CHEMBL762824
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against phosphodiesterase 5 (PDE5) obtained from human corpus cavernosum tissue
30
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological activity of beta-carboline-based type-5 phosphodiesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.03 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282515 | — | — | 2 | 9.15 |
| CHEMBL418594 | — | — | 1 | 8.92 |
| CHEMBL284070 | — | — | 1 | 8.82 |
| CHEMBL33518 | — | — | 1 | 8.72 |
| CHEMBL33121 | — | — | 1 | 8.70 |
| CHEMBL32255 | — | — | 1 | 8.68 |
| CHEMBL33627 | — | — | 1 | 8.60 |
| CHEMBL34276 | — | — | 1 | 8.57 |
| CHEMBL285737 | — | — | 1 | 8.44 |
| CHEMBL286309 | — | — | 1 | 8.40 |
| CHEMBL34628 | — | — | 1 | 8.40 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 8.17 |
| CHEMBL34802 | — | — | 1 | 8.15 |
| CHEMBL33147 | — | — | 1 | 8.08 |
| CHEMBL34744 | — | — | 1 | 7.89 |
| CHEMBL33381 | — | — | 1 | 7.88 |
| CHEMBL284560 | — | — | 2 | 7.81 |
| CHEMBL33944 | — | — | 1 | 7.80 |
| CHEMBL284059 | — | — | 1 | 7.77 |
| CHEMBL284627 | — | — | 1 | 7.70 |
| CHEMBL286905 | — | — | 1 | 7.58 |
| CHEMBL30936 | — | — | 1 | 7.25 |
| CHEMBL284258 | — | — | 1 | 7.24 |
| CHEMBL34169 | — | — | 1 | 6.90 |
| CHEMBL284535 | — | — | 1 | 6.88 |
| CHEMBL284594 | — | — | 1 | 6.87 |
| CHEMBL284719 | — | — | 1 | 6.79 |
| CHEMBL284745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282515 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL282515 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL418594 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL284070 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL33518 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL33121 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL32255 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL33627 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL34276 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL285737 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL286309 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL34628 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL779 | TADALAFIL | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL34802 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL33147 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL34744 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL33381 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL284560 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL33944 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL284059 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL284627 | — | IC50 | = | 19.8 | nM | 7.70 |
| CHEMBL286905 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL284560 | — | IC50 | = | 28.6 | nM | 7.54 |
| CHEMBL30936 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL284258 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL34169 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL284535 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL284594 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL284719 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL284745 | — | IC50 | > | 1000.0 | nM | - |