Compound Detail
CHEMBL284719
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O=C1[C@H]2Cc3c([nH]c4ccccc34)[C@@H](c3ccc4c(c3)OCO4)N2C(=O)CN1C1CN(Cc2ccccc2)C1
Basic Information
| ChEMBL ID | CHEMBL284719 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MULHHQYCMOKVQR-FYBSXPHGSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
520.6
MW (Da)
3.47
ALogP
5
HBA
1
HBD
78.1
PSA (Ų)
0.45
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.79
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 6.79 | 6.79 | 164.0 | 1 |
| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A CHEMBL2717 | IC50 | 6.02 | 6.02 | 950.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 164.0 | nM | 6.79 | Inhibitory activity against phosphodiesterase 5 (PDE5) obtained from human corpu... | 12668004 |
| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | IC50 | = | 950.0 | nM | 6.02 | Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombina... | 12668004 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12668004 | 10.1016/s0960-894x(03)00159-8 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
| 12668004 | 10.1016/s0960-894x(03)00159-8 | Phosphodiesterase 6 | 1 |
| 12668004 | 10.1016/s0960-894x(03)00159-8 | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | 1 |
Data from ChEMBL 36 via Core Engine