Assay Detail
Binding
CHEMBL759930
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression
27
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (CHEMBL2717) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological activity of beta-carboline-based type-5 phosphodiesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.74 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282515 | — | — | 2 | 8.85 |
| CHEMBL284070 | — | — | 1 | 8.70 |
| CHEMBL33518 | — | — | 1 | 8.62 |
| CHEMBL418594 | — | — | 1 | 8.46 |
| CHEMBL33121 | — | — | 1 | 8.38 |
| CHEMBL285737 | — | — | 1 | 8.37 |
| CHEMBL286309 | — | — | 1 | 8.33 |
| CHEMBL33627 | — | — | 1 | 8.33 |
| CHEMBL32255 | — | — | 1 | 8.26 |
| CHEMBL34744 | — | — | 1 | 8.19 |
| CHEMBL34276 | — | — | 1 | 8.17 |
| CHEMBL284560 | — | — | 2 | 7.93 |
| CHEMBL34802 | — | — | 1 | 7.66 |
| CHEMBL33381 | — | — | 1 | 7.51 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 7.43 |
| CHEMBL34169 | — | — | 1 | 7.41 |
| CHEMBL33944 | — | — | 1 | 7.37 |
| CHEMBL284627 | — | — | 1 | 7.32 |
| CHEMBL33147 | — | — | 1 | 7.32 |
| CHEMBL284594 | — | — | 1 | 7.28 |
| CHEMBL284535 | — | — | 1 | 7.15 |
| CHEMBL284059 | — | — | 1 | 7.07 |
| CHEMBL34628 | — | — | 1 | 6.93 |
| CHEMBL284719 | — | — | 1 | 6.02 |
| CHEMBL284745 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282515 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL284070 | — | IC50 | = | 2.01 | nM | 8.70 |
| CHEMBL282515 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL33518 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL418594 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL33121 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL285737 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL33627 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL286309 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL32255 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL34744 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL34276 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL284560 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL34802 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL33381 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL779 | TADALAFIL | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL34169 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL33944 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL284560 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL33147 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL284627 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL284594 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL284535 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL284059 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL34628 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL284719 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL284745 | — | IC50 | = | 1000.0 | nM | 6.00 |