Assay Detail
Binding
CHEMBL760752
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Inhibition of Phosphodiesterase 1
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.74 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112996 | — | — | 2 | 5.24 |
| CHEMBL2111730 | — | — | 1 | 4.85 |
| CHEMBL418848 | — | — | 1 | 4.80 |
| CHEMBL109754 | — | — | 1 | 4.28 |
| CHEMBL113368 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112996 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2111730 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL418848 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL112996 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL109754 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL113368 | — | IC50 | > | 100000.0 | nM | - |