Assay Detail
Binding
CHEMBL760754
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Inhibition of Phosphodiesterase 1 of guinea pig cardiac ventricle
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.24 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552876 | — | — | 1 | 5.70 |
| CHEMBL536568 | — | — | 1 | 5.70 |
| CHEMBL12383 | — | — | 1 | 5.70 |
| CHEMBL552877 | — | — | 1 | 5.52 |
| CHEMBL536801 | — | — | 1 | 5.40 |
| CHEMBL12412 | — | — | 1 | 5.30 |
| CHEMBL274528 | — | — | 1 | 5.05 |
| CHEMBL557593 | T-2585.HCL | — | 1 | 5.00 |
| CHEMBL537465 | — | — | 1 | 4.70 |
| CHEMBL12599 | — | — | 1 | 4.30 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
| CHEMBL553539 | — | — | 1 | - |
| CHEMBL536785 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552876 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL536568 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL12383 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL552877 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL536801 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL12412 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL274528 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL557593 | T-2585.HCL | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL537465 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL12599 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL63 | ROLIPRAM | IC50 | > | 100000.0 | nM | - |
| CHEMBL553539 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL536785 | — | IC50 | > | 100000.0 | nM | - |