Assay Detail
Binding
CHEMBL760772
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In vitro inhibitory activity against Prostaglandin G/H synthase in rat neutrophils
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Antiinflammatory activity of substituted 6-hydroxypyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-triones. Atypical nonsteroidal antiinflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.33 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154 | NAPROXEN | 4.0 | 1 | 7.22 |
| CHEMBL527 | PIROXICAM | 4.0 | 1 | 7.00 |
| CHEMBL13184 | — | — | 1 | 5.70 |
| CHEMBL13013 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154 | NAPROXEN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL527 | PIROXICAM | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL13184 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL13013 | — | IC50 | = | 4200.0 | nM | 5.38 |