Assay Detail
Functional
CHEMBL760811
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity against human progesterone receptor in T47D breast cancer cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | T47D |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as selective progesterone receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 7.73 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 9.48 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.74 |
| CHEMBL130141 | — | — | 1 | 8.34 |
| CHEMBL336751 | — | — | 1 | 8.31 |
| CHEMBL134277 | — | — | 1 | 8.26 |
| CHEMBL133117 | — | — | 1 | 8.10 |
| CHEMBL335996 | — | — | 1 | 8.10 |
| CHEMBL337856 | — | — | 1 | 8.05 |
| CHEMBL413309 | — | — | 1 | 7.96 |
| CHEMBL132363 | — | — | 1 | 7.92 |
| CHEMBL130257 | — | — | 1 | 7.75 |
| CHEMBL415524 | — | — | 1 | 7.75 |
| CHEMBL336736 | — | — | 1 | 7.72 |
| CHEMBL336169 | — | — | 1 | 7.68 |
| CHEMBL336353 | — | — | 1 | 7.58 |
| CHEMBL134602 | — | — | 1 | 7.55 |
| CHEMBL302362 | — | — | 1 | 7.55 |
| CHEMBL335249 | — | — | 1 | 7.54 |
| CHEMBL422444 | — | — | 1 | 7.39 |
| CHEMBL335879 | — | — | 1 | 7.36 |
| CHEMBL422268 | — | — | 1 | 7.32 |
| CHEMBL334586 | — | — | 1 | 7.30 |
| CHEMBL132672 | — | — | 1 | 7.27 |
| CHEMBL133483 | — | — | 1 | 7.23 |
| CHEMBL334747 | — | — | 1 | 7.01 |
| CHEMBL133124 | — | — | 1 | 6.79 |
| CHEMBL132578 | — | — | 1 | 6.72 |
| CHEMBL132256 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | EC50 | = | 0.33 | nM | 9.48 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL130141 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL336751 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL134277 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL133117 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL335996 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL337856 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL413309 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL132363 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL130257 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL415524 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL336736 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL336169 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL336353 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL134602 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL302362 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL335249 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL422444 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL335879 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL422268 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL334586 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL132672 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL133483 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL334747 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL133124 | — | EC50 | = | 161.0 | nM | 6.79 |
| CHEMBL132578 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL132256 | — | EC50 | = | - | nM | - |