Assay Detail
Functional
CHEMBL760813
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity to the human progesterone receptor (hPR)assayed in CV-1 cells in cotransfection assay.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 7.65 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 9.82 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.54 |
| CHEMBL323324 | — | — | 1 | 8.10 |
| CHEMBL430855 | — | — | 1 | 8.10 |
| CHEMBL103237 | — | — | 1 | 8.10 |
| CHEMBL318513 | — | — | 1 | 7.89 |
| CHEMBL103232 | — | — | 1 | 7.85 |
| CHEMBL102720 | — | — | 1 | 7.85 |
| CHEMBL286595 | — | — | 1 | 7.85 |
| CHEMBL103092 | — | — | 1 | 7.80 |
| CHEMBL101907 | — | — | 1 | 7.77 |
| CHEMBL102754 | — | — | 1 | 7.77 |
| CHEMBL317921 | — | — | 1 | 7.75 |
| CHEMBL320690 | — | — | 1 | 7.75 |
| CHEMBL320423 | — | — | 1 | 7.60 |
| CHEMBL102602 | — | — | 1 | 7.57 |
| CHEMBL321584 | — | — | 1 | 7.48 |
| CHEMBL102403 | — | — | 1 | 7.43 |
| CHEMBL102541 | — | — | 1 | 7.30 |
| CHEMBL101914 | — | — | 1 | 6.81 |
| CHEMBL101852 | — | — | 1 | 5.77 |
| CHEMBL102179 | — | — | 1 | 5.41 |
| CHEMBL103468 | — | — | 1 | - |
| CHEMBL320411 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL323324 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL430855 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL103237 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL318513 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL103232 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL102720 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL286595 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL103092 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL101907 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL102754 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL317921 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL320690 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL320423 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL102602 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL321584 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL102403 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL102541 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL101914 | — | EC50 | = | 156.0 | nM | 6.81 |
| CHEMBL101852 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL102179 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL103468 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL320411 | — | EC50 | > | 10000.0 | nM | - |