Assay Detail
Functional
CHEMBL760814
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity was measured for modulation of hPR-B (human progesterone receptor) in co-transfected CV-1 cells.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as potent, orally active, nonsteroidal progesterone receptor agonists: the effect of D-ring substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 8.21 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 9.82 |
| CHEMBL1162 | NORETHINDRONE | 4.0 | 1 | 8.66 |
| CHEMBL94749 | — | — | 1 | 8.57 |
| CHEMBL416411 | — | — | 1 | 8.55 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.54 |
| CHEMBL107998 | — | — | 1 | 8.51 |
| CHEMBL104183 | — | — | 1 | 8.44 |
| CHEMBL322485 | — | — | 1 | 8.43 |
| CHEMBL320164 | — | — | 1 | 8.30 |
| CHEMBL322576 | — | — | 1 | 8.28 |
| CHEMBL318409 | — | — | 1 | 8.16 |
| CHEMBL319915 | — | — | 1 | 8.15 |
| CHEMBL104037 | — | — | 1 | 8.13 |
| CHEMBL431807 | — | — | 1 | 8.13 |
| CHEMBL106994 | — | — | 1 | 8.09 |
| CHEMBL322575 | — | — | 1 | 8.05 |
| CHEMBL94753 | — | — | 1 | 8.03 |
| CHEMBL104347 | — | — | 1 | 8.02 |
| CHEMBL418990 | — | — | 1 | 8.00 |
| CHEMBL108230 | — | — | 1 | 8.00 |
| CHEMBL322312 | — | — | 1 | 7.89 |
| CHEMBL286595 | — | — | 1 | 7.82 |
| CHEMBL320632 | — | — | 1 | 7.82 |
| CHEMBL104451 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL1162 | NORETHINDRONE | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL94749 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL416411 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 2.89 | nM | 8.54 |
| CHEMBL107998 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL104183 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL322485 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL320164 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL322576 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL318409 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL319915 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL104037 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL431807 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL106994 | — | EC50 | = | 8.1 | nM | 8.09 |
| CHEMBL322575 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL94753 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL104347 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL418990 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL108230 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL322312 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL286595 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL320632 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL104451 | — | EC50 | = | 270.0 | nM | 6.57 |